Mobile Cancer Stem Cells – The Real Bad Guys? - New Model of Metastasis Formation Presented in Berlin

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Omschrijving
Mobile cancer stem cells can form metastases in colon cancer and other malignant tumours. Professor Thomas Brabletz from the University Hospital Freiburg, Germany, has developed a new model, which he presented at the International Conference “Invasion and Metastasis” held at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin. “Therefore, mobile cancer stem cells are the most dangerous cells for cancer patients,” he said. Until recently researchers assumed that every single tumour cell could form metastases. According to the World Health Organization, 655,000 people die from colon cancer every year. After lung cancer, it is the second most common cause of cancer-related deaths. This type of cancer arises from glands of the colon mucosa. It often goes unnoticed during the initial stage of development. Indeed, affected patients rarely present with pain or other symptoms, and thus the cancer is often not spotted until dangerous metastases have already developed. Cancer stem cells in colon cancer develop from colon stem cells, Professor Brabletz stated. These stem cells normally ensure that colon cells, which have a very short life span, are replaced each day. When such a stem cell becomes a cancer stem cell, it can divide infinitely and produce more cancer stem cells. In the second step of development, the altered cell detaches from the primary tumour and is then able to disseminate through blood or lymphatic vessels in the body.

 

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Categorie: darmkanker

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