The Immune System and Cancer - New Insights into a Not Always Healthy Interplay

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Omschrijving
For a long time, scientists believed that the immune system acted to fight cancer development. However, recent findings demonstrate that the immune system also acts to promote cancer progression. At the International conference “Invasion and Metastasis” held at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, Dr. David DeNardo from the laboratory of Professor Lisa Coussens from the University of California, San Francisco, USA reported on how tumours use immune cells to grow faster and disseminate in the body. When germs infiltrate a wound after injury, the body can well defend itself. Immune cells recognize the pathogens and initiate inflammation to limit infection. Attracted by this warning, many different cells of the immune system migrate to the centre of inflammation to help fight off the intruders. The injured area gets hot and red and becomes more sensitive and swollen. When the healing process is completed, inflammation abates and the immune cells withdraw. When some types of immune cells encounter tumour cells, they can also cause inflammation. Compared to normal injury, however, these immune cells often do not withdraw, but rather generate an enduring, chronic inflammation. “Therefore, we call tumours wounds that never heal,” Dr. DeNardo illustrated.

 

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