Evaluation of the current knowledge limitations in breast cancer research

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Omschrijving
Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included (1) genetics: knowledge of genetic changes, their effects and interactions; (2) initiation of breast cancer: how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation; (3) progression of breast cancer: deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis; (4) therapies and targets: understanding who develops advanced disease; (5) disease markers: incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers; (6) prevention: strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours; (7) psychosocial aspects of cancer: the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds.

 

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Categorie: borstkanker

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